S-Adenosyl-L-methionine

Brief Introduction of S-Adenosyl-L-methionine:

Name: S-Adenosyl-L-methionine(SAMe)

Synonyms: S-Adenosyl-L-Methionine Disulfate Tosylate, S-(5'-Adenosyl)-L-methionine, S-Adenosyl methionine, (3S)-5'-[(3-Amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine; SAMe, SAM-e,SAM

Molecular formula: C15H23N6O5S

Molecular weight : 398.44

CAS No.: 29908-03-0

Assay: 98%

Characteristic: White fine powder


Function and Usage of S-Adenosyl-L-methionine:

SAMe is a molecule produced constantly by all living cells. It is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury; has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.. SAMe has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.


Certificate of Analysis for S-Adenosyl-L-methionine:

ItemSpecificationResults
Appearance:A white or almost white powderConform
IdentificationConformConform
Clarity and color of solutionConformConform
Ph(acid value)1.5-2.52.1
Heavy metal content≤10ppmConform
Water content≤6.0%4.20%
S-adenosyl-L-Homocystein≤5.0%Conform
Methithioadenosine≤2.0%Conform
Adenine≤0.5%Conform
Total of impurities≤4.0%Conform
(S,S)Isomer>65.0% (HPLC)89.70%
Butanedisulfonate≤53.0% (by chemical)46.50%
Ademetionine ion (HPLC)45.0%--55.0%52.10%
Endotoxins≤0.35 EU/mgConform
Total plate count≤1000/gConform
Yeast and mould≤100/gConform
Staphylococcus aureusNegativeConform
E.coliNegativeConform
SalmonellaNegativeConform
Pseudomonas aeruginosaNegativeConform


Introduction of S-Adenosyl-L-methionine:

1. S-Adenosyl-L-methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

2. The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.

3. In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.

The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases (EC 2.1.1) that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAM, completing the cycle.

4. Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

5. SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

6. In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.


Indication of S-Adenosyl-L-methionine:

1.SAMe is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury;

2.SAMe has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.

3.SAMe has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.

Title:

Summary:

                 

S-Adenosyl-L-methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

本網站由阿里云提供云計算及安全服務
上海十一选五开奖结果快 安徽快3二同号单选遗漏数据 北京快乐10分 排列3技巧 七星彩杀号定胆 云南快乐10分前三组走势走势图 北京pk10预测软件 天津快乐十分在线投注 安徽11选5前三遗漏数据 时时彩专业版手机下载 山东11选五中奖技巧 大智慧手机炒股可靠吗 广东十一选五号码推荐 广东福彩快乐十开奖结果 北京赛车app苹果下载 云南11选五5中奖规则 黑龙江十一选五开奖结果定牛